Time course of autoantibodies to pancreatic islet cells in relatives of patients with type 1 diabetes mellitus
https://doi.org/10.14341/probl11583
Abstract
The incidence and levels of autoantibodies to Langerhans islet cell antigens (ICA) were studied in 261 children of patients with type I diabetes mellitus. ICA were detected in 14.8%) (19/128) clinically healthy siblings and 7.5% (10/133) children one of whose parents suffered from diabetes. 8.6%) children of diabetic fathers and 6.7%> children of diabetic mothers were ICA-positive. Age-associated regularities in ICA incidence in the examined groups were determined. Twenty-eight ICA-positive children were examined repeatedly after 11-21 months in order to evaluate the time course of the autoimmune process. More dynamic course of the process, which manifested by fluctuations in ICA levels, was observed in the siblings.
About the Authors
N. L. VartanyanResearch Institute of Influenza, RAMS
Russian Federation
A. A. Sominina
Research Institute of Influenza, RAMS
Russian Federation
V. V. Zarubaev
Research Institute of Influenza, RAMS
Russian Federation
A. S. Stroikova
Research Institute of Influenza, RAMS
Russian Federation
I. N. Ostretsova
Research Institute of Influenza, RAMS
Russian Federation
О. I. Kiselev
Research Institute of Influenza, RAMS
Russian Federation
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Review
For citations:
Vartanyan N.L., Sominina A.A., Zarubaev V.V., Stroikova A.S., Ostretsova I.N., Kiselev О.I. Time course of autoantibodies to pancreatic islet cells in relatives of patients with type 1 diabetes mellitus. Problems of Endocrinology. 2001;47(4):27-29. (In Russ.) https://doi.org/10.14341/probl11583
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